{"id":7873,"date":"2024-06-26T15:26:57","date_gmt":"2024-06-26T13:26:57","guid":{"rendered":"https:\/\/trigenotoul.com\/?p=7873"},"modified":"2024-06-26T15:26:57","modified_gmt":"2024-06-26T13:26:57","slug":"cancer-chromatin-compartment-dna-lesions","status":"publish","type":"post","link":"https:\/\/trigenotoul.com\/en\/cancers-compartiment-chromatiend-lesions-adn\/","title":{"rendered":"Cancers: discovery of the DNA damage-induced D-chromatin compartment"},"content":{"rendered":"<h5>DNA double-strand breaks can lead to the appearance of translocations, which result from the exchange of genetic material between two chromosomes. Translocations can cause cancers, but they can also be the consequence of chemotherapy treatments, thereby generating secondary tumours. The formation of translocations within our genome is still poorly understood, even though it is known to involve the spatial clustering of two breaks.<\/h5>\n<p>&nbsp;<\/p>\n<hr \/>\n<figure id=\"attachment_7874\" aria-describedby=\"caption-attachment-7874\" style=\"width: 527px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-7874\" src=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2024\/04\/chromatinD-1.jpg\" alt=\"Chromatin compartment D\" width=\"527\" height=\"466\" \/><figcaption id=\"caption-attachment-7874\" class=\"wp-caption-text\">\u00a9 Arnould et Legube<\/figcaption><\/figure>\n<p style=\"text-align: justify;\">By studying double-strand break repair and the three-dimensional organisation of our genome, Gaelle Legube\u2019s team at the CBI has demonstrated that, following the appearance of breaks, our DNA undergoes organisational changes in its structure. In particular, double-strand breaks lead to the formation of a new chromatin compartment called the D compartment. This compartment contains different breaks that cluster together in the same place, which promotes the occurrence of translocations with detrimental effects on genome stability. However, this D compartment also brings together certain genes that play a vital role in signalling the presence of damage to the cell. The presence of these genes in this D compartment would facilitate their activation, thereby enabling the cell to respond effectively to the threats posed by double-strand DNA breaks. Thus, the cell would have a selective advantage in maintaining this D compartment.<\/p>\n<p style=\"text-align: justify;\">This study sheds light on our understanding of the impact of the three-dimensional organisation of our DNA on the mechanisms that the cell sets up to cope with the danger caused by double-strand DNA breaks. But the flip side of the coin is that this organisation can occasionally lead to adverse effects for the cell by generating chromosomal translocations, which are deleterious events at the origin of cancers.<\/p>\n<p>&nbsp;<\/p>\n<blockquote>\n<h5>Publication<\/h5>\n<p><strong>Chromatin compartmentalization regulates the response to DNA damage<\/strong> \u2013 Coline Arnould#, Vincent Rocher#, Florian Saur, Aldo S. Bader, Fernando Muzzopappa, Sarah Collins, Emma Lesage, Benjamin Le Bozec, Nadine Puget, Thomas Clouaire, Thomas Mangeat, Raphael Mourad, Nadav Ahituv, Daan Noordermeer, Fabian Erdel, Martin Bushell, Aline Marnef, and Ga\u00eblle Legube, Nature 2023<\/p><\/blockquote>\n<hr \/>\n<p>Article published as part of the highlights <a href=\"https:\/\/www.genotoul.fr\/\" target=\"_blank\" rel=\"noopener\">GENOTOUL<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Les cassures double brins de l\u2019ADN peuvent conduire \u00e0 l\u2019apparition de translocations, qui r\u00e9sultent de\u00a0l\u2019\u00e9change de mat\u00e9riel g\u00e9n\u00e9tique entre deux chromosomes. Les translocations peuvent \u00eatre \u00e0 l\u2019origine de cancers, mais elles peuvent \u00e9galement \u00eatre la cons\u00e9quence de chimioth\u00e9rapies g\u00e9n\u00e9rant ainsi des tumeurs secondaires. La formation des translocations au sein de notre g\u00e9nome reste encore mal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7874,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7873","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cancers: d\u00e9couverte du compartiment chromatien D induit par les l\u00e9sions de l&#039;ADN - TRI-Genotoul<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trigenotoul.com\/en\/cancer-chromatin-compartment-dna-lesions\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cancers: d\u00e9couverte du compartiment chromatien D induit par les l\u00e9sions de l&#039;ADN - TRI-Genotoul\" \/>\n<meta property=\"og:description\" content=\"Les cassures double brins de l\u2019ADN peuvent conduire \u00e0 l\u2019apparition de translocations, qui r\u00e9sultent de\u00a0l\u2019\u00e9change de mat\u00e9riel g\u00e9n\u00e9tique entre deux chromosomes. Les translocations peuvent \u00eatre \u00e0 l\u2019origine de cancers, mais elles peuvent \u00e9galement \u00eatre la cons\u00e9quence de chimioth\u00e9rapies g\u00e9n\u00e9rant ainsi des tumeurs secondaires. 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