{"id":6995,"date":"2022-02-18T15:32:42","date_gmt":"2022-02-18T14:32:42","guid":{"rendered":"https:\/\/trigenotoul.com\/?p=6995"},"modified":"2022-02-18T15:32:42","modified_gmt":"2022-02-18T14:32:42","slug":"latest-generation-of-cryo-em-in-the-meti-technical-facilities","status":"publish","type":"post","link":"https:\/\/trigenotoul.com\/en\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/","title":{"rendered":"Latest generation of cryo-EM in the METi technical facilities"},"content":{"rendered":"<h5>The METi platform now houses a fully automated cryo-electron microscope (Talos Arctica, ThermoFisher Scientific) equipped with a direct electron detection camera coupled to an energy loss filter (K2 summit BioQuantum, Gatan). This transmission electron microscope, dedicated to high resolution\/high throughput observation of biological and organic samples frozen in amorphous ice is now fully operational.<\/h5>\n<hr \/>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft wp-image-6974\" src=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica2-1.jpg\" alt=\"Talos Arctica\" width=\"300\" height=\"230\" \/> <img decoding=\"async\" class=\"alignleft wp-image-6973\" src=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica1-1.jpg\" alt=\"Talos Arctica\" width=\"300\" height=\"276\" \/><\/p>\n<p>One of the major applications of cryo-electron microscopy is macromolecules 3D structure determination at a quasi-atomic scale. This approach, which recently was used to access coronaviruses structure, opens up important perspectives in structural biology, pharmacology, virology, enzymology&#8230; During the qualification tests, a first series of image acquisition led to the determination of the structure of apoferritin, a \u00ab\u00a0test\u00a0\u00bb enzyme well known of structural biologists, with a resolution of 2.35 \u00c5 in a few days.<\/p>\n<p>&nbsp;<\/p>\n<p>This Talos Arctica will also make it possible to study the three-dimensional structure of cells or other nano-objects, biological or not, by cryo-electron tomography. With this new device, Toulouse joins the small club of French sites equipped with high-throughput \/ high-resolution cryo-microscopes. Installed in the new 4R4 building of the <a href=\"https:\/\/trigenotoul.com\/en\/tri-genotoul-2\/our-platforms\/\">Center for Integrative Biology<\/a>, the Toulouse Talos Arctica is now open to the whole sceintific community.<\/p>\n<figure id=\"attachment_6975\" aria-describedby=\"caption-attachment-6975\" style=\"width: 1364px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"size-full wp-image-6975\" src=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1.jpg\" alt=\"Prises de vues par le Talos Artica\" width=\"1364\" height=\"349\" srcset=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1.jpg 1364w, https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1-300x77.jpg 300w, https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1-1024x262.jpg 1024w, https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1-768x197.jpg 768w, https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1-900x230.jpg 900w, https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1-150x38.jpg 150w, https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica3-1-1320x338.jpg 1320w\" sizes=\"(max-width: 1364px) 100vw, 1364px\" \/><figcaption id=\"caption-attachment-6975\" class=\"wp-caption-text\">Apoferritin molecules observed on the Toulouse Talos Arctica microcope (right) and 3D structure of apoferritin resolved at 2.35 \u00c5 (middle: global surface view; right: structure detail and derived atomic model).<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<hr \/>\n<blockquote>\n<h3>Contact et booking<\/h3>\n<ul>\n<li>Contact : <a href=\"mailto:stephanie.balor@utoulouse.fr\"><strong>St\u00e9phanie Balor<\/strong><\/a><\/li>\n<li><strong><a href=\"https:\/\/vm-tridb.toulouse.INRAe.fr\/\" target=\"_blank\" rel=\"noopener\">Online booking (registred users)<\/a><\/strong><\/li>\n<\/ul>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"<p>The METi platform now houses a fully automated cryo-electron microscope (Talos Arctica, ThermoFisher Scientific) equipped with a direct electron detection camera coupled to an energy loss filter (K2 summit BioQuantum, Gatan). This transmission electron microscope, dedicated to high resolution\/high throughput observation of biological and organic samples frozen in amorphous ice is now fully operational. One [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6974,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-6995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Latest generation of cryo-EM in the METi technical facilities - TRI-Genotoul<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trigenotoul.com\/en\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Latest generation of cryo-EM in the METi technical facilities - TRI-Genotoul\" \/>\n<meta property=\"og:description\" content=\"The METi platform now houses a fully automated cryo-electron microscope (Talos Arctica, ThermoFisher Scientific) equipped with a direct electron detection camera coupled to an energy loss filter (K2 summit BioQuantum, Gatan). This transmission electron microscope, dedicated to high resolution\/high throughput observation of biological and organic samples frozen in amorphous ice is now fully operational. One [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/trigenotoul.com\/en\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/\" \/>\n<meta property=\"og:site_name\" content=\"TRI-Genotoul\" \/>\n<meta property=\"article:published_time\" content=\"2022-02-18T14:32:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica2-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"639\" \/>\n\t<meta property=\"og:image:height\" content=\"479\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gesteve\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gesteve\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/\"},\"author\":{\"name\":\"gesteve\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#\\\/schema\\\/person\\\/71018a7e00cf92ab28949e5339a08591\"},\"headline\":\"Latest generation of cryo-EM in the METi technical facilities\",\"datePublished\":\"2022-02-18T14:32:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/\"},\"wordCount\":249,\"publisher\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/trigenotoul.com\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/talosartica2-1.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/\",\"url\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/\",\"name\":\"Latest generation of cryo-EM in the METi technical facilities - TRI-Genotoul\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/trigenotoul.com\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/talosartica2-1.jpg\",\"datePublished\":\"2022-02-18T14:32:42+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/#primaryimage\",\"url\":\"https:\\\/\\\/trigenotoul.com\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/talosartica2-1.jpg\",\"contentUrl\":\"https:\\\/\\\/trigenotoul.com\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/talosartica2-1.jpg\",\"width\":639,\"height\":479,\"caption\":\"Talos Artica\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/trigenotoul.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Latest generation of cryo-EM in the METi technical facilities\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#website\",\"url\":\"https:\\\/\\\/trigenotoul.com\\\/\",\"name\":\"TRI-Genotoul\",\"description\":\"Imagerie, cytom\u00e9trie &amp; analyse de donn\u00e9es pour les sciences du vivant\",\"publisher\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/trigenotoul.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#organization\",\"name\":\"TRI-Genotoul\",\"url\":\"https:\\\/\\\/trigenotoul.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/trigenotoul.com\\\/wp-content\\\/uploads\\\/2017\\\/01\\\/ImagerieTRI_logo-Q3-1.png\",\"contentUrl\":\"https:\\\/\\\/trigenotoul.com\\\/wp-content\\\/uploads\\\/2017\\\/01\\\/ImagerieTRI_logo-Q3-1.png\",\"width\":1000,\"height\":273,\"caption\":\"TRI-Genotoul\"},\"image\":{\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/trigenotoul.com\\\/#\\\/schema\\\/person\\\/71018a7e00cf92ab28949e5339a08591\",\"name\":\"gesteve\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/3ff90361fbad07b87db6e94afed78c806805bda9f3278f580caffd3dfd7e27e9?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/3ff90361fbad07b87db6e94afed78c806805bda9f3278f580caffd3dfd7e27e9?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/3ff90361fbad07b87db6e94afed78c806805bda9f3278f580caffd3dfd7e27e9?s=96&d=mm&r=g\",\"caption\":\"gesteve\"},\"sameAs\":[\"https:\\\/\\\/trigenotoul.com\\\/newsite\"],\"url\":\"https:\\\/\\\/trigenotoul.com\\\/en\\\/author\\\/gesteve\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Latest generation of cryo-EM in the METi technical facilities - TRI-Genotoul","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/trigenotoul.com\/en\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/","og_locale":"en_GB","og_type":"article","og_title":"Latest generation of cryo-EM in the METi technical facilities - TRI-Genotoul","og_description":"The METi platform now houses a fully automated cryo-electron microscope (Talos Arctica, ThermoFisher Scientific) equipped with a direct electron detection camera coupled to an energy loss filter (K2 summit BioQuantum, Gatan). This transmission electron microscope, dedicated to high resolution\/high throughput observation of biological and organic samples frozen in amorphous ice is now fully operational. One [&hellip;]","og_url":"https:\/\/trigenotoul.com\/en\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/","og_site_name":"TRI-Genotoul","article_published_time":"2022-02-18T14:32:42+00:00","og_image":[{"width":639,"height":479,"url":"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica2-1.jpg","type":"image\/jpeg"}],"author":"gesteve","twitter_card":"summary_large_image","twitter_misc":{"Written by":"gesteve","Estimated reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/#article","isPartOf":{"@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/"},"author":{"name":"gesteve","@id":"https:\/\/trigenotoul.com\/#\/schema\/person\/71018a7e00cf92ab28949e5339a08591"},"headline":"Latest generation of cryo-EM in the METi technical facilities","datePublished":"2022-02-18T14:32:42+00:00","mainEntityOfPage":{"@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/"},"wordCount":249,"publisher":{"@id":"https:\/\/trigenotoul.com\/#organization"},"image":{"@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/#primaryimage"},"thumbnailUrl":"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica2-1.jpg","articleSection":["News"],"inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/","url":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/","name":"Latest generation of cryo-EM in the METi technical facilities - TRI-Genotoul","isPartOf":{"@id":"https:\/\/trigenotoul.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/#primaryimage"},"image":{"@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/#primaryimage"},"thumbnailUrl":"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica2-1.jpg","datePublished":"2022-02-18T14:32:42+00:00","breadcrumb":{"@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/#primaryimage","url":"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica2-1.jpg","contentUrl":"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/talosartica2-1.jpg","width":639,"height":479,"caption":"Talos Artica"},{"@type":"BreadcrumbList","@id":"https:\/\/trigenotoul.com\/latest-generation-of-cryo-em-in-the-meti-technical-facilities\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/trigenotoul.com\/"},{"@type":"ListItem","position":2,"name":"Latest generation of cryo-EM in the METi technical facilities"}]},{"@type":"WebSite","@id":"https:\/\/trigenotoul.com\/#website","url":"https:\/\/trigenotoul.com\/","name":"TRI-Genotoul","description":"Imagerie, cytom\u00e9trie &amp; analyse de donn\u00e9es pour les sciences du vivant","publisher":{"@id":"https:\/\/trigenotoul.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/trigenotoul.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/trigenotoul.com\/#organization","name":"TRI-Genotoul","url":"https:\/\/trigenotoul.com\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/trigenotoul.com\/#\/schema\/logo\/image\/","url":"https:\/\/trigenotoul.com\/wp-content\/uploads\/2017\/01\/ImagerieTRI_logo-Q3-1.png","contentUrl":"https:\/\/trigenotoul.com\/wp-content\/uploads\/2017\/01\/ImagerieTRI_logo-Q3-1.png","width":1000,"height":273,"caption":"TRI-Genotoul"},"image":{"@id":"https:\/\/trigenotoul.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/trigenotoul.com\/#\/schema\/person\/71018a7e00cf92ab28949e5339a08591","name":"gesteve","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/3ff90361fbad07b87db6e94afed78c806805bda9f3278f580caffd3dfd7e27e9?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/3ff90361fbad07b87db6e94afed78c806805bda9f3278f580caffd3dfd7e27e9?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/3ff90361fbad07b87db6e94afed78c806805bda9f3278f580caffd3dfd7e27e9?s=96&d=mm&r=g","caption":"gesteve"},"sameAs":["https:\/\/trigenotoul.com\/newsite"],"url":"https:\/\/trigenotoul.com\/en\/author\/gesteve\/"}]}},"_links":{"self":[{"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/posts\/6995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/comments?post=6995"}],"version-history":[{"count":0,"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/posts\/6995\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/media\/6974"}],"wp:attachment":[{"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/media?parent=6995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/categories?post=6995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/trigenotoul.com\/en\/wp-json\/wp\/v2\/tags?post=6995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}