{"id":6947,"date":"2022-02-14T18:01:36","date_gmt":"2022-02-14T17:01:36","guid":{"rendered":"https:\/\/trigenotoul.com\/?p=6947"},"modified":"2022-02-14T18:01:36","modified_gmt":"2022-02-14T17:01:36","slug":"identification-of-blood-vessels-that-allow-killer-lymphocytes-to-access-tumours","status":"publish","type":"post","link":"https:\/\/trigenotoul.com\/en\/cell-identification-des-vaisseaux-sanguins-qui-permettent-aux-lymphocytes-tueurs-dacceder-aux-tumeurs\/","title":{"rendered":"CELL: identification of the blood vessels that allow killer lymphocytes to access tumours"},"content":{"rendered":"<h5>As part of an article published in the journal <strong>Cancer Cell,<\/strong> An IPBS team, with the assistance of the imaging platform and the Gustave Roussy Institute, has discovered the essential role played by specific blood vessels, known as HEV vessels, in the response to immunotherapy and the infiltration of \u2018killer\u2019 lymphocytes into tumours. Scientists have managed to film for the first time lymphocytes squeezing through the wall of HEV vessels to enter tumours.<\/h5>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"50%\"><div style=\"width: 578px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-6947-1\" width=\"578\" height=\"538\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/GIRARD-Video-Vaisseau-HEV-et-entree-des-lymphocytes-dans-une-tumeur-online-video-cutter.com_-1.mp4?_=1\" \/><a href=\"https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/GIRARD-Video-Vaisseau-HEV-et-entree-des-lymphocytes-dans-une-tumeur-online-video-cutter.com_-1.mp4\">https:\/\/trigenotoul.com\/wp-content\/uploads\/2022\/02\/GIRARD-Video-Vaisseau-HEV-et-entree-des-lymphocytes-dans-une-tumeur-online-video-cutter.com_-1.mp4<\/a><\/video><\/div><\/td>\n<td>\n<p style=\"text-align: justify;\">Researchers have on the one hand shown, in animal models, that increasing the proportion of HEV vessels in a tumour improves the efficacy of immunotherapy. On the other hand, clinical studies in humans have demonstrated the increased probability of recovery in patients suffering from metastatic melanoma (skin cancer) and treated with immunotherapy when a large number of HEV vessels are present in the tumours. The results of this study are published in the journal Cancer Cell on 3 February 2022.<\/p>\n<p>&nbsp;<\/p>\n<p><em>Microscopy visualisation of lymphocytes (in green) squeezing through a tumour HEV vessel (in red) during anti-PD-1 plus anti-CTLA-4 immunotherapy treatment. Note the lymphocyte just to the left of the centre of the video leaving the vessel to enter the tumour (in black).\u00a0<\/em><\/p>\n<p><em>Video: E. BELLARD &amp; J.-P. GIRARD \u2013 IPBS (CNRS\/UT3 Paul Sabatier)<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<hr \/>\n<blockquote>\n<h4>More information<\/h4>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ccell.2022.01.002\" target=\"_blank\" rel=\"noopener\"><strong>Tumor-associated high endothelial venules mediate lymphocyte entry into tumours and predict response to PD-1 plus CTLA-4 combination immunotherapy<\/strong><\/a> \u2013 <strong>Cancer Cell<\/strong><br \/>\nAssia Asrir, Claire Tardiveau, Juliette Coudert, Robin Laffont, Lucas Blanchard, Elisabeth Bellard, Krystle Veerman, Sarah Bettini, Fanny Lafouresse, Estefania Vina, Dorian Tarroux, Severine Roy, Isabelle Girault, Irma Molinaro, Fr\u00e9d\u00e9ric Martins, Jean-Yves Scoazec, Nathalie Ortega, Caroline Robert et Jean-Philippe Girard.<\/li>\n<li><strong>Contact:<\/strong> <a href=\"mailto:elisabeth.bellard@ipbs.fr\"><strong>Elisabeth Bellard <\/strong><\/a><strong>or <a href=\"mailto:jean-philippe.girard@ipbs.fr\">Jean-Philippe Girard<\/a><\/strong><\/li>\n<\/ul>\n<\/blockquote>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Dans le cadre d&rsquo;une publication parue dans le revue Cancer Cell, une \u00e9quipe de l&rsquo;IPBS avec le concours de la plateforme imagerie et de l&rsquo;institut Gustave Roussy a d\u00e9couvert le r\u00f4le essentiel jou\u00e9 par des vaisseaux sanguins particuliers, appel\u00e9s vaisseaux HEV, dans la r\u00e9ponse \u00e0 l&rsquo;immunoth\u00e9rapie et l\u2019infiltration des lymphocytes \u2018tueurs\u2019 dans les tumeurs. Les [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6967,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6947","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CELL : identification des vaisseaux sanguins qui permettent aux lymphocytes tueurs d\u2019acc\u00e9der aux tumeurs - TRI-Genotoul<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trigenotoul.com\/en\/identification-of-blood-vessels-that-allow-killer-lymphocytes-to-access-tumours\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CELL : identification des vaisseaux sanguins qui permettent aux lymphocytes tueurs d\u2019acc\u00e9der aux tumeurs - TRI-Genotoul\" \/>\n<meta property=\"og:description\" content=\"Dans le cadre d&rsquo;une publication parue dans le revue Cancer Cell, une \u00e9quipe de l&rsquo;IPBS avec le concours de la plateforme imagerie et de l&rsquo;institut Gustave Roussy a d\u00e9couvert le r\u00f4le essentiel jou\u00e9 par des vaisseaux sanguins particuliers, appel\u00e9s vaisseaux HEV, dans la r\u00e9ponse \u00e0 l&rsquo;immunoth\u00e9rapie et l\u2019infiltration des lymphocytes \u2018tueurs\u2019 dans les tumeurs. 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