{"id":6792,"date":"2021-08-18T15:36:50","date_gmt":"2021-08-18T13:36:50","guid":{"rendered":"https:\/\/trigenotoul.com\/?p=6792"},"modified":"2021-08-18T15:36:50","modified_gmt":"2021-08-18T13:36:50","slug":"identification-of-key-adaptations-for-host-persistence-of-tb-bacilli","status":"publish","type":"post","link":"https:\/\/trigenotoul.com\/en\/identification-of-key-adaptations-for-host-persistence-of-tb-bacilli\/","title":{"rendered":"Identification of key adaptations for host persistence of TB bacilli"},"content":{"rendered":"
Tuberculosis is an infectious disease that still kills 1.5 million people per year worldwide. The causative bacteria probably emerged from an environmental source through adaptations of already existing metabolic pathways. By replicating this evolution in the laboratory, the researchers were able to identify mutations in the bacterial genome that favour persistence in the host lungs. These adaptations allow the bacterium to better resist aggression by the immune response. The revelation of these adaptation pathways opens new avenues of research in the fight against this disease. As co-author, the IPBS TRI technology facilities led by A. Peixoto was involved in designing and performing image analysis for the study. The results of this study are published on 23 July in the journal Nature Microbiology.<\/em><\/h5>\n

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\"Necrotic
Necrotic pulmonary lesions generated in the mouse model by the tuberculosis bacillus. The sections were stained by the Ziehl-Neelsen method and reveal the bacteria in pink that persist in the necrotic zone of the lesion (in blue). \u00a9 Samantha Milia, Service d\u2019Histopathologie Exp\u00e9rimentale (CREFRE, INSERM, Toulouse)<\/em><\/figcaption><\/figure>\n

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